Center for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Molecules. 2010 Mar 17;15(3):1932-57. doi: 10.3390/molecules15031932.
Lipid vesicles spontaneously fuse and assemble into a lipid bilayer on planar or spherical silica surfaces and other substrates. The supported lipid bilayers (SLBs) maintain characteristics of biological membranes, and are thus considered to be biomembrane mimetic systems that are stable because of the underlying substrate. Examples of their shared characteristics with biomembranes include lateral fluidity, barrier formation to ions and molecules, and their ability to incorporate membrane proteins into them. Biomimetic silica microspheres consisting of SLBs on solid or porous silica microspheres have been utilized for different biosensing applications. The advantages of such biomimetic microspheres for biosensing include their increased surface area to volume ratio which improves the detection limits of analytes, and their amenability for miniaturization, multiplexing and high throughput screening. This review presents examples and formats of using such biomimetic solid or porous silica microspheres in biosensing.
脂质体在平面或球形二氧化硅表面和其他基底上自发融合并组装成脂质双层。支撑脂质双层（SLB）保持生物膜的特性，因此被认为是稳定的生物膜模拟系统，因为底层基底的存在。它们与生物膜的共同特性的例子包括横向流动性、对离子和分子的屏障形成，以及它们将膜蛋白纳入其中的能力。由固体或多孔二氧化硅微球上的 SLB 组成的仿生二氧化硅微球已被用于不同的生物传感应用。这种仿生微球在生物传感中的优点包括增加了表面积与体积比，从而提高了分析物的检测限，以及易于小型化、多重化和高通量筛选。本综述介绍了在生物传感中使用这种仿生固体或多孔二氧化硅微球的示例和形式。
