T(H)2 型免疫应答是如何启动和放大的？
How are T(H)2-type immune responses initiated and amplified?
机构信息
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Nat Rev Immunol. 2010 Apr;10(4):225-35. doi: 10.1038/nri2735.
Abstract
CD4(+) T helper (T(H)) cells have crucial roles in orchestrating adaptive immune responses. T(H)2 cells control immunity to extracellular parasites and all forms of allergic inflammatory responses. Although we understand the initiation of the T(H)2-type response in tissue culture in great detail, much less is known about T(H)2 cell induction in vivo. Here we discuss the involvement of allergen- and parasite product-mediated activation of epithelial cells, basophils and dendritic cells and the functions of the cytokines interleukin-4 (IL-4), IL-25, IL-33 and thymic stromal lymphopoietin in the initiation and amplification of T(H)2-type immune responses in vivo.
摘要
CD4(+) T 辅助细胞（T(H)）在调节适应性免疫反应中起着至关重要的作用。T(H)2 细胞控制对外寄生虫和所有形式的过敏炎症反应的免疫。尽管我们非常详细地了解组织培养中 T(H)2 型反应的启动，但对体内 T(H)2 细胞的诱导知之甚少。在这里，我们讨论了过敏原和寄生虫产物介导的上皮细胞、嗜碱性粒细胞和树突状细胞的激活，以及白细胞介素-4（IL-4）、IL-25、IL-33 和胸腺基质淋巴生成素在体内 T(H)2 型免疫反应的启动和放大中的作用。
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