Pan Hong, Han Qing-Ping, Zeng Min-Ling, Wang Fang, Xiong Ying, Wu Bo, Yu Hai-Ying
Department of Internal Medicine, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Department of Dermatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Front Neurol. 2025 Jul 18;16:1630671. doi: 10.3389/fneur.2025.1630671. eCollection 2025.
BACKGROUND/OBJECTIVES: Recent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the potential relationship between these two conditions.
A comprehensive literature search was conducted across PubMed, Embase, and Web of Science from their inception until January 2025 to identify observational studies examining the association between atopic dermatitis and stroke risk. Random-effects meta-analyses were performed using the generic inverse variance method, and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Additionally, sensitivity analyses and subgroup analyses were conducted to assess the stability of the results and explore potential sources of heterogeneity.
This meta-analysis included 12 observational studies, comprising 8 cohort studies, 2 case-control studies, and 3 cross-sectional studies, with a total of 14,517,146 participants. The analysis revealed a significant correlation between AD and the risk of stroke ( = 17, OR = 1.27, 95%CI = 1.14-1.43). Subgroup analyses indicated a particularly strong association among males ( = 3, OR = 1.31, 95% CI = 1.07-1.60) and in the context of ischemic stroke types ( = 5, OR = 1.14 95%CI = 1.00-1.30). Furthermore, sensitivity analyses demonstrated that the results were stable and reliable.
AD is independently associated with an increased risk of stroke, especially in men, and there is a notable association with ischemic stroke. Moreover, the risk appears to be positively correlated with the severity of AD.
Identifier INPLASY202550006.
背景/目的：近期研究试图确定特应性皮炎（AD）与中风发生之间的相关性；然而，这些调查尚未达成共识。因此，我们团队进行了这项荟萃分析和系统评价，以进一步探讨这两种情况之间的潜在关系。
从创刊至2025年1月，在PubMed、Embase和Web of Science上进行了全面的文献检索，以确定考察特应性皮炎与中风风险之间关联的观察性研究。使用通用逆方差法进行随机效应荟萃分析，并计算95%置信区间（CI）的风险比（HR）。此外，进行了敏感性分析和亚组分析，以评估结果的稳定性并探索异质性的潜在来源。
这项荟萃分析纳入了12项观察性研究，包括8项队列研究、2项病例对照研究和3项横断面研究，共有14517146名参与者。分析显示AD与中风风险之间存在显著相关性（ = 17，OR = 1.27，95%CI = 1.14 - 1.43）。亚组分析表明，男性（ = 3，OR = 1.31，95%CI = 1.07 - 1.60）以及在缺血性中风类型中（ = 5，OR = 1.14，95%CI = 1.00 - 1.30）的关联尤为强烈。此外，敏感性分析表明结果稳定可靠。
AD与中风风险增加独立相关，尤其是在男性中，并且与缺血性中风存在显著关联。此外，风险似乎与AD的严重程度呈正相关。
标识符INPLASY202550006
