Oueghlani Evelyne, O'Sullivan Eoin, Pavesio Carlos E
Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, UK.
Int Ophthalmol. 2010 Oct;30(5):615-9. doi: 10.1007/s10792-010-9358-z. Epub 2010 Mar 25.
We describe the first two cases of diffuse unilateral subacute neuroretinitis (DUSN) in the UK successfully treated with albendazole. Two patients are described who presented with unilateral reduction in vision, with clusters of yellow-white retinal lesions fading and reappearing in new locations of the fundus over a period of weeks. Based on the clinical picture, the diagnosis of DUSN was made, even though no subretinal worm could be found. Both patients were treated with albendazole 400 mg daily for 30 days. After 4 weeks the vision in the affected eye improved to 6/9 in each patient and the retinal lesions resolved completely. Over a follow-up period of 28 months and 13 months respectively, there was no recurrence of any lesion and the vision was maintained. DUSN is a sight-threatening disease and the preservation of vision relies on early diagnosis and treatment. Laser photocoagulation of the worm is the treatment of choice, but this was not possible in either case, as no worm could be found; however, oral albendazole proved to be a safe and effective alternative treatment.
我们描述了英国首例成功使用阿苯达唑治疗的两例弥漫性单侧亚急性神经视网膜炎（DUSN）。文中介绍了两名患者，他们均出现单眼视力下降，眼底可见黄白色视网膜病灶簇，在数周内于眼底新部位消退并再次出现。基于临床表现，尽管未发现视网膜下蠕虫，但仍诊断为DUSN。两名患者均接受每日400毫克阿苯达唑治疗，持续30天。4周后，每位患者患眼视力均提高到6/9，视网膜病灶完全消退。在分别为期28个月和13个月的随访期内，未出现任何病灶复发，视力得以维持。DUSN是一种威胁视力的疾病，视力的保留依赖于早期诊断和治疗。对蠕虫进行激光光凝是首选治疗方法，但这两例均无法进行，因为未发现蠕虫；然而，口服阿苯达唑被证明是一种安全有效的替代治疗方法。
