McLin Valerie A, Shah Rina, Desai Neekita P, Jamrich Milan
Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine, Houston, TX, USA.
Int J Dev Biol. 2010;54(5):919-24. doi: 10.1387/ijdb.092916vm.
FoxF genes are essential for visceral mesoderm development from Drosophila to human. However, part of the difficulty of studying the visceral mesoderm is its relative inaccessibility during early development. Owing to its external development Xenopus laevis presents considerable advantages for the study of visceral mesoderm formation, yet FoxF2 has not been identified in this system. Here, we describe the cloning and expression pattern of XFoxF2 during embryonic development, metamorphosis and adulthood, and compare and contrast it to the expression of FoxF1 in Xenopus laevis and FoxF2 in mouse.
从果蝇到人类，FoxF基因对于内脏中胚层的发育至关重要。然而，研究内脏中胚层的部分困难在于其在早期发育过程中相对难以获取。由于非洲爪蟾的体外发育，它在研究内脏中胚层形成方面具有相当大的优势，但在这个系统中尚未鉴定出FoxF2。在这里，我们描述了XFoxF2在胚胎发育、变态发育和成年期的克隆及表达模式，并将其与非洲爪蟾中FoxF1和小鼠中FoxF2的表达进行比较和对比。
