三维能量多普勒血管造影在子宫内膜癌中的应用：与肿瘤特征的相关性。

Three-dimensional power Doppler angiography in endometrial cancer: correlation with tumor characteristics.

机构信息

Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

出版信息

Ultrasound Obstet Gynecol. 2010 Jun;35(6):723-9. doi: 10.1002/uog.7633.

DOI:10.1002/uog.7633

PMID:20336639

Abstract

OBJECTIVE

To assess the correlation between intratumoral vascularization using three-dimensional power Doppler angiography (3D-PDA) and several histological tumor characteristics in a series of patients with endometrial carcinoma.

METHODS

Ninety-nine women (mean age, 61.7 (range, 31-84) years) diagnosed as having endometrial cancer were assessed by transvaginal 3D-PDA before surgical staging. Endometrial volume (EV) and 3D-PDA vascular indices (vascularization index (VI), flow index (FI) and vascularization flow index (VFI)) were calculated using the Virtual Organ Computer-aided AnaLysis (VOCAL) method. All patients were surgically staged. Individual tumor features such as histological type, tumor grade, myometrial infiltration depth, lymph-vascular space involvement, cervical involvement, lymph node metastases and tumor stage were considered for analysis. Multivariate logistic regression (MLR) analysis was used to determine which 3D-PDA parameters were independently associated with each histological characteristic.

RESULTS

MLR analysis showed that only EV and VI were independently associated with myometrial infiltration (EV: odds ratio (OR), 1.119 (95% CI, 1.025-1.221), P = 0.012; VI: OR, 1.127 (95% CI, 1.063-1.195), P = 0.001) and tumor stage (EV: OR, 1.103 (95% CI, 1.012-1.202), P = 0.025; VI: OR, 1.120 (95% CI, 1.057-1.187), P = 0.001), only VI was independently associated with tumor grade (OR, 1.056 (95% CI, 1.023-1.091), P = 0.001) and only EV was independently associated with lymph node metastases (OR, 1.086 (95% CI, 1.017-1.161), P = 0.001).

CONCLUSION

3D-PDA analysis of tumor vascularization in endometrial cancer correlates with some prognostic histological characteristics.

摘要

目的

通过三维能量多普勒血管造影（3D-PDA）评估一系列子宫内膜癌患者肿瘤内血管生成与几种组织学肿瘤特征之间的相关性。

方法

99 名被诊断为患有子宫内膜癌的女性（平均年龄 61.7 岁（范围 31-84 岁））在手术分期前通过经阴道 3D-PDA 进行评估。使用虚拟器官计算机辅助分析（VOCAL）方法计算子宫内膜体积（EV）和 3D-PDA 血管指数（血管化指数（VI）、流量指数（FI）和血管化流量指数（VFI））。所有患者均进行手术分期。考虑分析个体肿瘤特征，如组织学类型、肿瘤分级、肌层浸润深度、淋巴血管空间侵犯、宫颈侵犯、淋巴结转移和肿瘤分期。采用多变量逻辑回归（MLR）分析确定哪些 3D-PDA 参数与每种组织学特征独立相关。

结果

MLR 分析表明，只有 EV 和 VI 与肌层浸润（EV：优势比（OR），1.119（95%置信区间，1.025-1.221），P=0.012；VI：OR，1.127（95%置信区间，1.063-1.195），P=0.001）和肿瘤分期（EV：OR，1.103（95%置信区间，1.012-1.202），P=0.025；VI：OR，1.120（95%置信区间，1.057-1.187），P=0.001）独立相关，仅 VI 与肿瘤分级（OR，1.056（95%置信区间，1.023-1.091），P=0.001）独立相关，仅 EV 与淋巴结转移（OR，1.086（95%置信区间，1.017-1.161），P=0.001）独立相关。