Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.
Int J Gynecol Cancer. 2010 Apr;20(3):393-7. doi: 10.1111/IGC.0b013e3181d159f9.
To evaluate whether tumor vascularity as assessed by 3-dimensional power Doppler angiography (3D-PDA) correlates with some tumor features in cervical cancer.
Clinical, sonographic, and histologic data on 56 women (mean age, 47.8 years; range, 27-81 years) with a diagnosis of carcinoma in the uterine cervix were analyzed. Tumor volume and 3D-PDA indexes (vascularization index, flow index, and vascularization flow index) were calculated in all cases. These data were correlated with some tumoral features such as histologic type, histologic grade, lymphovascular space involvement, lymph node metastases, and tumor stage.
Intratumoral blood flow was found in all cases. No correlation was found between tumor volume and 3D-PDA indexes with histologic type, lymphovascular space involvement, and lymph node metastases. Moderately and poorly differentiated tumors and advanced-stage tumors had larger volume and 3D-PDA indexes (P < 0.05).
Our data indicate that tumor vascularization as assessed by 3D-PDA correlates with some tumor features in cervical cancer.
评估三维能量多普勒血管造影（3D-PDA）评估的肿瘤血管生成与宫颈癌的某些肿瘤特征是否相关。
对 56 名经诊断患有宫颈癌的妇女（平均年龄 47.8 岁；范围 27-81 岁）的临床、超声和组织学数据进行分析。对所有病例计算肿瘤体积和 3D-PDA 指标（血管化指数、血流指数和血管化血流指数）。这些数据与一些肿瘤特征相关，如组织学类型、组织学分级、血管淋巴管间隙浸润、淋巴结转移和肿瘤分期。
所有病例均发现肿瘤内血流。肿瘤体积和 3D-PDA 指标与组织学类型、血管淋巴管间隙浸润和淋巴结转移之间无相关性。中低分化肿瘤和晚期肿瘤的体积和 3D-PDA 指数较大（P<0.05）。
我们的数据表明，3D-PDA 评估的肿瘤血管生成与宫颈癌的某些肿瘤特征相关。
