Department of Psychiatry and Psychotherapy, Philipps-University Marburg, 35039 Marburg, Germany.
Hum Brain Mapp. 2011 Jan;32(1):118-26. doi: 10.1002/hbm.21005.
The D-amino acid oxidase activator gene (G72) has been found associated with several psychiatric disorders such as schizophrenia, major depression, and bipolar disorder. Impaired performance in verbal fluency tasks is an often replicated finding in the mentioned disorders. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and lateral temporal areas and could possibly constitute an endophenotype. Therefore, it is of interest whether genes associated with the disorders, such as G72, modulate verbal fluency performance and its neural correlates. Ninety-six healthy individuals performed a semantic verbal fluency task while brain activation was measured with functional MRI. All subjects were genotyped for two single nucleotide polymorphisms (SNP) in the G72 gene, M23 (rs3918342) and M24 (rs1421292), that have previously shown association with the above-mentioned disorders. The effect of genotype on brain activation was assessed with fMRI during a semantic verbal fluency task. Although there were no differences in performance, brain activation in the right middle temporal gyrus (BA 39) and the right precuneus (BA 7) was positively correlated with the number of M24 risk alleles in the G72 gene. G72 genotype does modulate brain activation during language production on a semantic level in key language areas. These findings are in line with structural and functional imaging studies in schizophrenia, which showed alterations in the right middle temporal gyrus.
D-氨基酸氧化酶激活基因（G72）已被发现与多种精神疾病有关，如精神分裂症、重度抑郁症和双相情感障碍。言语流畅性任务表现受损是这些疾病中经常被重复发现的现象。在功能神经影像学研究中，这种功能障碍与前额叶和外侧颞叶区域的信号变化有关，可能构成一个表型。因此，与这些疾病相关的基因，如 G72，是否调节言语流畅性表现及其神经相关性，这是一个值得关注的问题。96 名健康个体在进行语义言语流畅性任务的同时，通过功能磁共振成像测量大脑激活。所有受试者均对 G72 基因中的两个单核苷酸多态性（SNP）M23（rs3918342）和 M24（rs1421292）进行了基因分型，这两个 SNP 先前与上述疾病有关。在语义言语流畅性任务期间，使用 fMRI 评估基因型对大脑激活的影响。尽管在表现上没有差异，但在右中颞叶（BA39）和右楔前叶（BA7）的大脑激活与 G72 基因中 M24 风险等位基因的数量呈正相关。G72 基因型确实会调节语言产生过程中语义水平上的大脑激活，关键语言区域。这些发现与精神分裂症的结构和功能影像学研究一致，该研究显示右中颞叶发生了改变。
