Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Cell Biochem. 2010 May 15;110(2):321-32. doi: 10.1002/jcb.22540.
Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB(1) receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy.
尽管大麻素在多种癌细胞类型中与抗肿瘤活性有关，但在胃癌细胞中的作用尚未阐明。在本研究中，我们研究了大麻素激动剂对胃癌细胞增殖和侵袭的影响。大麻素激动剂 WIN 55,212-2 呈剂量依赖性抑制人胃癌细胞的增殖，这种作用部分是通过 CB(1)受体介导的。我们还发现 WIN 55,212-2 诱导人胃癌细胞凋亡和下调磷酸化 AKT 的表达。此外，WIN 55,212-2 处理抑制胃癌细胞的侵袭，并通过大麻素受体下调 MMP-2 和 VEGF-A 的表达。我们的结果为将大麻素用作新的胃癌治疗方法提供了可能性。
