1987 年至 2005 年间，智利瓦尔迪维亚地区医院就诊的鼻腔淋巴瘤患者中， Epstein-Barr 病毒的流行情况。

Prevalence of Epstein-Barr virus associated with nasal lymphoma in patients attending the regional hospital of Valdivia, Chile, between 1987 and 2005.

机构信息

Institute of Anatomy, Histology, Pathology, Faculty of Medicine, University Austral of Chile, Valdivia, Chile.

出版信息

J Med Virol. 2010 May;82(5):825-8. doi: 10.1002/jmv.21705.

PMID:20336747

Abstract

Epstein-Barr virus (EBV) is a ubiquitous herpes virus with a widespread infection in the world's adult population. EBV has been associated with human malignancies, mainly the nasal type NK/T cell lymphoma. The disease is more frequent in Asian than in Western countries. However, there are few studies from Latin American countries. The aim of this study was to determine the prevalence of EBV in patients with nasal lymphomas diagnosed in the Regional Hospital of Valdivia, southern Chile, during 1987-2005. Immunohistochemistry was done on paraffin sections using anti-CD3epsilon, anti-CD20, and anti-CD56. The presence of small ribonucleic acids (RNAs) of EBV was detected in paraffin sections by in situ hybridization using oligonucleotides targeting EBV-encoded small RNAs. The present study revealed a prevalence of 27.7% of Hodgkin's lymphomas and 72.3% of non-Hodgkin's lymphomas. From the latter group, there was a prevalence of 2.9% (10 cases) of nasal lymphoma. From these 10 cases, 6 (60%) were NK/T cell lymphomas, nasal type; 1 case (10%) was a T-cell phenotype; and 3 cases (30%) were B-cell phenotype. The prevalence was higher than reports from Western countries, but lower than the reports from Asian countries. These results agreed with previous reports suggesting that EBV is strongly associated with T lymphomas. This study contributes new epidemiological data on EBV in Chile.

摘要

EB 病毒（EBV）是一种普遍存在的疱疹病毒，在世界成年人群中有广泛的感染。EBV 与人类恶性肿瘤有关，主要是鼻腔型 NK/T 细胞淋巴瘤。这种疾病在亚洲比在西方国家更为常见。然而，来自拉丁美洲国家的研究很少。本研究旨在确定智利南部瓦尔迪维亚地区医院在 1987-2005 年间诊断的鼻腔淋巴瘤患者中 EBV 的流行率。使用抗 CD3epsilon、抗 CD20 和抗 CD56 对石蜡切片进行免疫组织化学染色。通过使用针对 EBV 编码小 RNA 的寡核苷酸进行原位杂交，在石蜡切片中检测到 EBV 的小核糖核酸（RNAs）的存在。本研究显示霍奇金淋巴瘤的流行率为 27.7%，非霍奇金淋巴瘤的流行率为 72.3%。在后一组中，有 2.9%（10 例）的鼻腔淋巴瘤。在这 10 例中，有 6 例（60%）为 NK/T 细胞淋巴瘤，鼻腔型；1 例（10%）为 T 细胞表型；3 例（30%）为 B 细胞表型。这一流行率高于西方国家的报告，但低于亚洲国家的报告。这些结果与先前的报告一致，表明 EBV 与 T 细胞淋巴瘤密切相关。本研究为 EBV 在智利的流行提供了新的流行病学数据。