Department of Anatomic Pathology, University of Indonesia/Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia.
Int J Hematol. 2010 Dec;92(5):681-9. doi: 10.1007/s12185-010-0738-y. Epub 2010 Dec 7.
Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.
自然杀伤 (NK) 细胞肿瘤是一组异质性疾病。在最新的 2008 年世界卫生组织 (WHO) 造血和淋巴组织肿瘤分类中，被认为是 NK 细胞起源的疾病实体包括 NK 淋巴母细胞白血病/淋巴瘤、NK 细胞慢性淋巴增殖性疾病、侵袭性 NK 细胞白血病和结外 NK/T 细胞淋巴瘤，鼻型。尽管 NK 细胞研究取得了最近的进展，扩大了我们对 NK 细胞肿瘤生物学的理解，但即使在一些“知名”实体中，如结外 NK/T 细胞淋巴瘤，也仍然无法与髓系肿瘤和 T 细胞肿瘤明确区分。本综述描述了当前对 NK 细胞生物学和 NK 肿瘤病理学的认识，这些内容在 2008 年 WHO 造血和淋巴组织肿瘤分类中进行了分类。
