Cancer Research Institute, School of Medicine, University of South China, Hengyang, China.
Jpn J Infect Dis. 2010 Mar;63(2):132-5.
To analyze the association of several types of malignant lymphomas in different anatomical sites with the Epstein-Barr virus (EBV) infection status, 127 cases of formalin-fixed paraffin-embedded samples of malignant lymphomas were investigated with in situ hybridization detecting EBV-encoded small RNA (EBER) in tumor cells. Forty-six out of 108 non-Hodgkin lymphoma (NHL) cases were positive for EBER (42.6%). The EBER-positivity rate of NHL in the nasal cavity and nasopharynx (35/60 cases, 58.3%) was higher than that of NHL in stomach (9/30 cases, 30%) and in the superficial lymph nodes (2/18 cases, 11.1%) (P<0.05). The EBER-positivity rate of Hodgkin lymphoma in the superficial lymph nodes was 26.3% (5/19 cases). These findings suggest that the EBV-positivity rate in lymphomas is related to their histological types and locations.
为分析不同解剖部位的几种恶性淋巴瘤与 Epstein-Barr 病毒（EBV）感染状态的关联，我们采用原位杂交法检测肿瘤细胞中的 EBV 编码的小 RNA（EBER），对 127 例福尔马林固定石蜡包埋的恶性淋巴瘤样本进行了研究。在 108 例非霍奇金淋巴瘤（NHL）病例中，有 46 例 EBER 阳性（42.6%）。鼻腔和鼻咽部 NHL 的 EBER 阳性率（35/60 例，58.3%）高于胃 NHL（9/30 例，30%）和浅表淋巴结 NHL（2/18 例，11.1%）（P<0.05）。浅表淋巴结霍奇金淋巴瘤的 EBER 阳性率为 26.3%（5/19 例）。这些发现表明，淋巴瘤中的 EBV 阳性率与其组织学类型和部位有关。
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