Essen A, Ozen H, Ayhan A, Ergen A, Tasar C, Remzi F
Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
J Urol. 1991 Jun;145(6):1134-7. doi: 10.1016/s0022-5347(17)38555-5.
Serum ferritin levels in 32 patients with renal cell carcinoma were evaluated preoperatively and postoperatively. Serum ferritin concentration was significantly higher in renal cell carcinoma patients compared to controls (259.10 versus 61.30 ng./ml., p less than 0.001). Furthermore, there was a steady and statistically significant increase in serum ferritin levels with advancing disease stage, as well as a significant decrease in serum ferritin levels after nephrectomy for stages 1 and 2 disease. The intracellular content of ferritin as estimated by polyclonal antibody was dramatically increased in renal cancer tissue compared to normal parenchyma. Although serum ferritin regulation is complex and only partly understood, the present study suggests that serum ferritin may be a useful tumor marker for renal cell carcinoma.
对32例肾细胞癌患者术前和术后的血清铁蛋白水平进行了评估。与对照组相比，肾细胞癌患者的血清铁蛋白浓度显著更高（259.10对61.30 ng./ml.，p<0.001）。此外，随着疾病分期的进展，血清铁蛋白水平呈稳定且具有统计学意义的升高，而对于1期和2期疾病，肾切除术后血清铁蛋白水平显著降低。与正常实质相比，通过多克隆抗体估计的肾癌组织中铁蛋白的细胞内含量显著增加。尽管血清铁蛋白的调节很复杂且仅部分被理解，但本研究表明血清铁蛋白可能是肾细胞癌的一种有用的肿瘤标志物。
