Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Cancer. 2010 Jun 15;116(12):2984-92. doi: 10.1002/cncr.25058.
The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).
Multivariate logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). False-positive report probabilities (FPRPs) also were calculated for significant findings.
The ADH7 A92G GG and combined CG + GG genotypes were associated with a decreased risk of SCCHN (GG: adjusted OR, 0.32; 95% CI, 0.13-0.82; CG + GG: adjusted OR, 0.74; 95% CI, 0.59-0.94; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older patients (aged >57 years), men, former smokers, patients with oral cancer, and patients with N) lymph node status (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP.
The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations.
作者对 1110 例头颈部鳞状细胞癌（SCCHN）患者和 1129 例对照组患者进行了一项基于医院的研究，以复制最近一项大型欧洲研究报告的 2 个潜在功能性单核苷酸多态性（SNP）与头颈部鳞状细胞癌风险之间的关联，即醇脱氢酶（ADH）基因中的一个氨基酸 48 位从精氨酸变为组氨酸的替换（参考 SNP 编号 [rs]1229984；鸟嘌呤变为腺嘌呤[G-->A]）和 ADH7 中氨基酸 92 位从丙氨酸变为甘氨酸的替换（rs1573496；胞嘧啶变为鸟嘌呤[C-->G]）。
使用多变量逻辑回归计算调整后的比值比（OR）和 95%置信区间（CI）。还计算了显著发现的假阳性报告概率（FPRP）。
ADH7 A92G GG 和 CG + GG 基因型与 SCCHN 风险降低相关（GG：调整 OR，0.32；95%CI，0.13-0.82；CG + GG：调整 OR，0.74；95%CI，0.59-0.94；FPRP，0.098）与 CC 基因型相比。这种关联在年龄较大的患者（>57 岁）、男性、前吸烟者、口腔癌患者和 N）淋巴结状态的亚组中也很明显（所有 P <.05）；然而，ADH1B R48H SNP 并未观察到这种关联。
目前的结果支持 ADH7 A92G SNP 作为非西班牙裔白人人群中 SCCHN 风险的标志物。
