Bowman Kimberly C, Tabrizian Parissa, Telem Dana A, Boudourakis Leon, Divino Celia M
Department of Surgery, Division of General Surgery, The Mount Sinai Hospital, New York, NY 10029, USA.
Am Surg. 2010 Feb;76(2):164-7.
The purpose of this study was to assess for disparity within a cohort of patients presenting with complicated colorectal cancer. A retrospective study of 522 patients who underwent surgery for colorectal cancer at a tertiary care institution was performed. Complicated cancer was defined by perforating or obstructing colonic lesions. Statistical analysis was conducted by chi2 test and analysis of variance. Of the 522 patients, 72 patients (14%) presented with complicated colorectal cancer. Blacks in low-income brackets (36 vs 0%, P < 0.001) and those with public insurance (55 vs 16%, P < 0.05) had increased presentation with complicated colorectal cancers as compared with whites. Black (91%) and Hispanic women (86%), when compared with white women (37%) had increased incidence of complicated colorectal cancer (P < 0.05). Patients in low-income brackets, regardless of race, had increased cancer recurrence rates (57 vs 8%, P < 0.001) compared with patients in average or high-income brackets. Mortality rate was 57 per cent in Hispanic, 29 per cent in white, and 27 per cent in black patients (P = nonsignificant). Specific targeting of colorectal cancer screening, education, and follow-up programs is imperative for minority women and patients of low socioeconomic status.
本研究的目的是评估一组患有复杂性结直肠癌患者之间的差异。对一家三级医疗机构中522例行结直肠癌手术的患者进行了回顾性研究。复杂性癌症定义为结肠穿孔或梗阻性病变。采用卡方检验和方差分析进行统计分析。在这522例患者中,72例(14%)患有复杂性结直肠癌。与白人相比,低收入阶层的黑人(36%对0%,P<0.001)和有公共保险的黑人(55%对16%,P<0.05)患复杂性结直肠癌的比例更高。与白人女性(37%)相比,黑人女性(91%)和西班牙裔女性(86%)患复杂性结直肠癌的发生率更高(P<0.05)。无论种族如何,低收入阶层的患者与平均或高收入阶层的患者相比,癌症复发率更高(57%对8%,P<0.001)。西班牙裔患者的死亡率为57%,白人患者为29%,黑人患者为27%(P无统计学意义)。对于少数族裔女性和社会经济地位较低的患者,必须针对性地开展结直肠癌筛查、教育和随访项目。