Li Dongming, Huang Xiaoqi, Wu Qizhu, Zou Keo, Sun Xueli, Gong Qiyong
Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Feb;27(1):16-9.
This study sought to reveal the difference in resting-state brain functions between subjects with major depressive disorder and normal controls. Fifty-three depressed patients diagnosed with DSM-IV and 38 normal controls underwent resting-state functional magnetic resonance imaging (fMRI), and the data were analyzed using a new method called Regional Homogeneity (ReHo). Then voxel wised comparison was made to derive the resting-state brain function differences between groups. Compared with normal controls, depressed subjects showed decreased ReHo in bilateral anterior cingulate cortex (ACC), left medial frontal gyrus, and left middle temporal gyrus. Significant decreased ReHo in ACC might suggest less spontaneous neuronal activities or lower baseline brain activities of ACC in depressed subjects in comparison with normal controls.
本研究旨在揭示重度抑郁症患者与正常对照组在静息态脑功能上的差异。53名被诊断为DSM-IV的抑郁症患者和38名正常对照组接受了静息态功能磁共振成像（fMRI），并使用一种名为局部一致性（ReHo）的新方法对数据进行分析。然后进行体素水平比较以得出两组之间静息态脑功能的差异。与正常对照组相比，抑郁症患者在双侧前扣带回皮质（ACC）、左侧额内侧回和左侧颞中回的ReHo降低。ACC中ReHo显著降低可能表明与正常对照组相比，抑郁症患者的ACC自发神经元活动较少或基线脑活动较低。
