Division of Mood Disorder, Shanghai Mental Health Center, Medical School of Colleague, Shanghai Jiao Tong University, Shanghai 200030, China.
Chin Med J (Engl). 2011 Feb;124(3):369-73.
Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity (ReHo) in depression by resting-state functional magnetic resonance imaging (fMRI).
Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs. healthy participants. Sixteen participants firstly diagnosed with major depressive disorder and 16 controls were scanned during resting state. A novel method based on ReHo was used to detect spontaneous hemodynamic responses across the whole brain.
ReHo in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of depression.
Abnormal spontaneous activity exists in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe. And the ReHo may be a potential reference in understanding the distinct brain activity in resting state of depression.
功能影像学研究表明，在任务或静息状态下，抑郁症患者皮质边缘网络的活动异常。本研究旨在通过静息态功能磁共振成像（fMRI）探讨抑郁症的局部一致性（ReHo）显示的异常自发活动。
使用 fMRI 测量静息状态下抑郁症患者与健康对照组之间的局部脑活动差异。16 名首次被诊断为重度抑郁症的患者和 16 名健康对照者在静息状态下进行了扫描。一种基于 ReHo 的新方法用于检测整个大脑的自发性血液动力学反应。
与健康对照组相比，抑郁症患者在静息状态下左侧丘脑、左侧颞叶、左侧小脑后叶和双侧枕叶的 ReHo 显著降低。
在静息状态下，左侧丘脑、左侧颞叶、左侧小脑后叶和双侧枕叶存在异常自发活动。ReHo 可能是理解抑郁症静息状态下不同脑活动的潜在参考。
