Fu Yuchuan, Li Guangjun, Lin Daquan, Jiang Qingfeng, Li Ping
Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Feb;27(1):193-7.
Craniospinal radiation is one of essential components in the treatment flow for a number of central nervous system malignancies. Meticulous attention to technique and dosimetry is required to produce optimum tumor control. In this paper, an optimized treatment regimen was proposed based on multiple techniques. The CT images for a 17-year-old male patient in need of craniospinal radiation were acquired for 3D conformal treatment planning. The split-beam technique, the extended penumbra fields matching technique, and the multiple leaf collimator segments and extended SSD technique were synthesized in the treatment regimen so as to work out an optimized treatment plan. The added few segments improved the dose homogeneity in spinal cord. The maximal point dose was decreased from 124% to 108% of the prescribed dose in it. Comparative study on the anthropomorphic phantom showed that the data collected by thermoluminescent detectors and the data obtained by calculation were basically coincident. These results suggest that the proposed technique be clinically acceptable.
全脑全脊髓放疗是多种中枢神经系统恶性肿瘤治疗流程中的重要组成部分之一。为实现最佳的肿瘤控制，需要对技术和剂量测定予以细致关注。本文基于多种技术提出了一种优化的治疗方案。获取了一名需要全脑全脊髓放疗的17岁男性患者的CT图像，用于三维适形治疗计划。该治疗方案综合了分束技术、半值层扩展野匹配技术以及多叶准直器分段和扩展源皮距技术，从而制定出优化的治疗计划。增加的少数射野改善了脊髓的剂量均匀性。其中最大剂量点从处方剂量的124%降至108%。对人体模型的对比研究表明，热释光探测器收集的数据与计算得到的数据基本一致。这些结果表明所提出的技术在临床上是可接受的。
