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[烯丙吗啡对周围刺激诱导的镇痛作用]

[The effect of nalorphine on analgesia induced by peripheral stimulation].

作者信息

Planche D, Farnarier G, Rohner J J

出版信息

C R Seances Soc Biol Fil. 1977;171(5):1059-63.

PMID:203372
Abstract

The blockade of effects induced by percutaneous peripheral stimulation were abolished by injection of an opiate antagonist as nalorphine. Our results lead to the hypothesis that central and peripheral stimulations act by the same mechanism in producing blockade of noxious impulses. One may suggest that peripheral stimulations induce release of endogenous morphine-like substances which in turn give descending inhibition.

摘要

注射阿片拮抗剂烯丙吗啡可消除经皮外周刺激所诱导的效应阻断。我们的结果引发了这样一个假说,即中枢和外周刺激在产生有害冲动阻断方面通过相同机制起作用。有人可能会提出,外周刺激会诱导内源性吗啡样物质的释放,而这些物质反过来会产生下行抑制。

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