Physiology and Medical Biochemistry, Zoology Department, Faculty of Science, Damanhour Branch, Alexandria University, Damanhour, AlBheira, Egypt.
Biomed Environ Sci. 2009 Dec;22(6):488-95. doi: 10.1016/S0895-3988(10)60006-2.
To investigate the possible mechanism by which curcumin protects stomach during the acute chronic phase of gastric ulcer disease.
The rats were divided into four groups and fasted for 2 days with free access to water. On the third day, the animals were fasted for a further 24 h with no access to water followed by surgery. Rats received different doses of curcumin (20, 40, and 80 mg/kg) or vehicle by oral gavage. Nineteen hours after ulcer induction, the rats were killed by decapitation. Stomach was opened along the greater curvature and ulcerative lesions were counted. Total juice acidity, neutrophils activity, mitochondrial activity, total antioxidants, paraoxonase (PON 1)/arylesterase and total peroxides were evaluated. DNA fragmentation (%) and pro-inflammatory cytokine IL-6 level were measured. The level of different gastro-cytoprotective effectors including total antioxidants and paraoxonase (PON 1)/arylesterase activities was measured.
The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase (MPO) activity, IL-6 and apoptotic incidence.
Curcumin appears to have a propitious protective effect against gastric ulcer development.
研究姜黄素在胃溃疡病急慢性期保护胃的可能机制。
将大鼠分为四组，禁食 2 天，自由饮水。第三天，动物再禁食 24 小时，不饮水，然后进行手术。大鼠口服给予不同剂量的姜黄素（20、40 和 80mg/kg）或载体。溃疡诱导后 19 小时，大鼠断头处死。沿胃大弯剪开胃，计数溃疡病灶。评估总胃液酸度、中性粒细胞活性、线粒体活性、总抗氧化剂、对氧磷酶（PON1）/芳酯酶和总过氧化物。测量 DNA 片段化（%）和促炎细胞因子 IL-6 水平。测量不同胃保护效应物的水平，包括总抗氧化剂和对氧磷酶（PON1）/芳酯酶活性。
姜黄素的抗溃疡活性表现为减弱胃酸分泌过多、总过氧化物、髓过氧化物酶（MPO）活性、IL-6 和细胞凋亡发生率等不同的溃疡效应物。
姜黄素似乎对胃溃疡的发展具有有利的保护作用。
