Alam Md Shamshir, Anwar Md Jamir, Maity Manish Kumar, Azam Faizul, Jaremko Mariusz, Emwas Abdul-Hamid
Department of Pharmacy Practice, College of Pharmacy, National University of Science and Technology, P.O. Box 620, Bosher, Muscat 130, Oman.
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.
Pharmaceuticals (Basel). 2024 Dec 11;17(12):1674. doi: 10.3390/ph17121674.
Herbal medicine, particularly in developing regions, remains highly popular due to its cost-effectiveness, accessibility, and minimal risk of adverse effects. L., commonly known as turmeric, exemplifies such herbal remedies with its extensive history of culinary and medicinal applications across Asia for thousands of years. Traditionally utilized as a dye, flavoring, and in cultural rituals, turmeric has also been employed to treat a spectrum of medical conditions, including inflammatory, bacterial, and fungal infections, jaundice, tumors, and ulcers. Building on this longstanding use, contemporary biochemical and clinical research has identified curcumin-the primary active compound in turmeric-as possessing significant therapeutic potential. This review hypothesizes that curcumin's antioxidant properties are pivotal in preventing and treating chronic inflammatory diseases, which are often precursors to more severe conditions, such as cancer, and neurological disorders, like Parkinson's and Alzheimer's disease. Additionally, while curcumin demonstrates a favorable safety profile, its anticoagulant effects warrant cautious application. This article synthesizes recent studies to elucidate the molecular mechanisms underlying curcumin's actions and evaluates its therapeutic efficacy in various human illnesses, including cancer, inflammatory bowel disease, osteoarthritis, atherosclerosis, peptic ulcers, COVID-19, psoriasis, vitiligo, and depression. By integrating diverse research findings, this review aims to provide a comprehensive perspective on curcumin's role in modern medicine and its potential as a multifaceted therapeutic agent.
草药，尤其是在发展中地区，因其成本效益高、易于获取且副作用风险极小而一直广受欢迎。姜黄，学名Curcuma longa L.，作为一种草药疗法的典范，在亚洲有着数千年广泛的烹饪和药用历史。姜黄传统上被用作染料、调味料，并用于文化仪式，还被用于治疗一系列病症，包括炎症、细菌和真菌感染、黄疸、肿瘤及溃疡。基于其长期的使用，当代生化和临床研究已确定姜黄素（姜黄中的主要活性化合物）具有巨大的治疗潜力。本综述假设姜黄素的抗氧化特性在预防和治疗慢性炎症性疾病中起着关键作用，而慢性炎症性疾病往往是癌症等更严重疾病以及帕金森病和阿尔茨海默病等神经疾病的先兆。此外，虽然姜黄素显示出良好的安全性，但它的抗凝作用需要谨慎应用。本文综合了近期的研究，以阐明姜黄素作用的分子机制，并评估其在包括癌症、炎症性肠病、骨关节炎、动脉粥样硬化、消化性溃疡、新冠肺炎、银屑病、白癜风和抑郁症等各种人类疾病中的治疗效果。通过整合不同的研究结果，本综述旨在全面阐述姜黄素在现代医学中的作用及其作为多方面治疗剂的潜力。
