Koç Aylin, Onal Sumru, Yenice Ozlem, Kazokoglu Haluk
Ophthalmic Surg Lasers Imaging. 2010 Mar 9:1-3. doi: 10.3928/15428877-20100215-35.
Candida endophthalmitis is a common cause of fungal endophthalmitis. A case of bilateral endogenous endophthalmitis caused by Candida albicans without candidemia in an otherwise healthy 77-year-old man was reported. The patient underwent bilateral pars plana vitrectomy and intravitreal liposomal amphotericin B injections in addition to systemic fluconazole therapy. Postoperatively, a significant decrease of inflammation and resolution of abscesses were observed in both eyes. Vision improved in the left eye but remained constant in the right eye because of secondary cataract formation. To the best of our knowledge, this is the first report on the use of liposomal amphotericin B intravitreally in a patient with bilateral endogenous candida endophthalmitis. No evidence of clinical ocular toxicity was observed with the liposomal form of amphotericin B injection.
念珠菌性眼内炎是真菌性眼内炎的常见病因。本文报道了一例77岁身体健康的男性患者，由白色念珠菌引起双侧内源性眼内炎且无念珠菌血症。该患者除接受全身性氟康唑治疗外，还接受了双侧玻璃体切除术及玻璃体内注射脂质体两性霉素B。术后，双眼炎症显著减轻，脓肿消退。左眼视力改善，但右眼因继发性白内障形成视力保持不变。据我们所知，这是首例关于脂质体两性霉素B玻璃体内注射治疗双侧内源性念珠菌性眼内炎患者的报道。脂质体形式的两性霉素B注射未观察到临床眼毒性证据。
