Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy.
Scand J Rheumatol. 2010 Mar;39(2):167-70. doi: 10.3109/03009740903313639.
Mixed cryoglobulinaemia (MC) is a chronic small-vessel vasculitis. Shortly after the discovery of hepatitis C virus (HCV) in 1989, an association between HCV infection and MC was being increasingly reported, suggesting the potential pathogenetic implication of HCV in most of the cases that had been previously diagnosed as essential MC. A number of studies have pointed out prognostic factors linked to mortality in this disorder. None of them, however, have clarified the impact of HCV discovery on the natural history of the disease. The aim of the present study was to evaluate mortality in MC after the discovery of HCV infection.
We retrospectively collected clinical and serological data in 70 unselected HCV-positive patients being followed up at our unit from 1990. Clinical and prognostic factors linked to poor outcome were evaluated.
Chronic hepatitis, renal involvement, and intestinal vasculitis were the most frequent causes of death.
Compared to other series, the outcome in our MC seemed to be better. Factors linked to a poor outcome were renal involvement, widespread vasculitis, male sex, and cryocrit.
混合性冷球蛋白血症（MC）是一种慢性小血管血管炎。1989 年丙型肝炎病毒（HCV）发现后不久，HCV 感染与 MC 之间的关联被越来越多地报道，这表明在以前被诊断为原发性 MC 的大多数病例中，HCV 可能具有潜在的致病作用。许多研究指出了与该疾病死亡率相关的预后因素。然而，它们都没有阐明 HCV 发现对疾病自然史的影响。本研究旨在评估 HCV 感染发现后 MC 的死亡率。
我们回顾性地收集了 1990 年以来在我们单位接受随访的 70 例未选择的 HCV 阳性患者的临床和血清学数据。评估了与不良预后相关的临床和预后因素。
慢性肝炎、肾受累和肠血管炎是最常见的死亡原因。
与其他系列相比，我们的 MC 结果似乎更好。与不良预后相关的因素包括肾受累、广泛的血管炎、男性和冷球蛋白。
