Imai T, Sannohe Y, Okano H
Cancer. 1978 Jan;41(1):358-64. doi: 10.1002/1097-0142(197801)41:1<358::aid-cncr2820410148>3.0.co;2-f.
An oat cell carcinoma occurring in the esophagus of a 62-year-old man is described. A strong argyrophilia of the oat cells together with the presence electron microscopically of neurosecretory type granules in their cytoplasm suggests a derivation of this tumor from the cells of the APUD series, and the tumor is diagnosed as apudoma. An aberrant columnar epithelium on the esophageal surface is presumed to be the source of its origin. A rapid postoperative course of the patient despite a rather circumscribed growth pattern of the primary tumor appears to characterize the clinical aspect of this case. An apparent accumulation of the cases with esophageal apudoma in Japan is discussed.
本文描述了一名62岁男性食管燕麦细胞癌的病例。燕麦细胞具有强烈的嗜银性，并且在电子显微镜下其细胞质中存在神经分泌型颗粒，这表明该肿瘤起源于APUD系列细胞，因此被诊断为APUD瘤。食管表面异常的柱状上皮被认为是肿瘤的起源部位。尽管原发肿瘤生长较为局限，但患者术后恢复迅速，这似乎是该病例的临床特点。本文还讨论了日本食管APUD瘤病例明显增多的现象。
