Morriss J A, Tymms D J
J Pathol. 1980 Jun;131(2):107-15. doi: 10.1002/path.1711310203.
A case of non-familial multiple APUD cell neoplasia is described in which an oat cell carcinoma occurred in association with a phaeochromocytoma and two gastric carcinoids. This is the first reported case in which an oat cell carcinoma has formed part of such a syndrome. The arguments for and against this being a chance association are briefly stated and it is suggested that this case provides some support for the view that oat cell carcinomas are themselves derived from APUD cells. The same patient had autoimmune disease, and although this may be purely fortuitous, a speculative hypothesis is advanced suggesting that the deranged anterior pituitary trophic function seen in Hashimoto's thyroiditis may have predisposed to multiple endocrine neoplasia in this case.
本文描述了一例非家族性多发性APUD细胞瘤，其中燕麦细胞癌与嗜铬细胞瘤和两个胃类癌同时发生。这是首次报道燕麦细胞癌成为此类综合征一部分的病例。简要阐述了支持和反对这是偶然关联的论据，并表明该病例为燕麦细胞癌本身源自APUD细胞的观点提供了一些支持。同一患者患有自身免疫性疾病，尽管这可能纯属偶然，但提出了一个推测性假说，即桥本甲状腺炎中所见的垂体前叶营养功能紊乱可能使该病例易患多发性内分泌肿瘤。
