Cataldo Franco
Actinium Chemical Research srl, via Casilina 1626/A, 00133 Rome, Italy.
Chem Phys Lipids. 2010 Jun;163(6):524-9. doi: 10.1016/j.chemphyslip.2010.03.004. Epub 2010 Mar 23.
Unsaturated lipids when exposed to air at room temperature undergo a slow autoxidation. When fullerene C(60) was dissolved in selected lipids (ethyl oleate, ethyl linoleate, linseed oil and castor oil) the spectrophotometric analysis shows that the oxidation is concentrated to C(60) which is converted to an epoxide C(60)O. Thus, fullerene C(60) displays antioxidant activity not only when dissolved in unsaturated lipids but also, more generally, when dissolved in unsaturated solvents subjected to autoxidation like, for example, in cyclohexene. The behaviour of C(60) in ethyl oleate has been compared with that of the known antioxidant TMPPD (N,N',N,N,'-tetramethyl-p-phenylenediamine) in ethyl oleate. The mechanism of the antioxidant action of C(60) in lipids has been proposed. The kinetics of C(60) oxidation in lipids was determined spectrophotometrically both at room temperature in the dark and under UV irradiation. The oxidized products derived from C(60) photo-oxidation in lipids have been identified.
不饱和脂质在室温下暴露于空气中会发生缓慢的自动氧化。当富勒烯C(60)溶解在选定的脂质（油酸乙酯、亚油酸乙酯、亚麻籽油和蓖麻油）中时，分光光度分析表明氧化作用集中于C(60)，C(60)会转化为环氧化物C(60)O。因此，富勒烯C(60)不仅在溶解于不饱和脂质时表现出抗氧化活性，更普遍地说，当溶解于会发生自动氧化的不饱和溶剂中时，如环己烯中，也表现出抗氧化活性。已将C(60)在油酸乙酯中的行为与已知抗氧化剂TMPPD（N,N',N,N,'-四甲基对苯二胺）在油酸乙酯中的行为进行了比较。已提出C(60)在脂质中的抗氧化作用机制。通过分光光度法在室温黑暗条件下以及紫外线照射下测定了C(60)在脂质中的氧化动力学。已鉴定出脂质中C(60)光氧化产生的氧化产物。
