Deruelle P, Girard J-M, Coutty N, Subtil D
Pôle d'obstétrique, hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille cedex, France.
Ann Fr Anesth Reanim. 2010 Mar;29(3):e31-5. doi: 10.1016/j.annfar.2010.02.014. Epub 2010 Mar 24.
Aspirin has shown efficacy in preventing PE with a 10 % incidence reduction. The treatment must be started between the 12(th) and 14(th) week of amenorrhea with a dose of 75 to 160 mg once daily. This treatment is all the more effective as it is given to a high risk population. The supplementation with 1,5 g of calcium per day appears effective as well in the prevention of PE, especially in the malnourished and young patents. Insufficient data is currently available to recommend antioxidant supplementation. Low molecular weight heparin is potentially beneficial in the prevention of PE, however its efficacy remains to be demonstrated and indications determined. Nitric oxide (NO) or NO releasers are not effective and can cause headaches. Diuretics reduce the birth weight without improving the incidence of PE.
阿司匹林已显示出预防肺栓塞的功效,可使发病率降低10%。治疗必须在闭经的第12至14周开始,剂量为每日75至160毫克,一次服用。这种治疗方法对高危人群更为有效。每天补充1.5克钙在预防肺栓塞方面似乎也有效,尤其是对营养不良的年轻患者。目前尚无足够数据推荐补充抗氧化剂。低分子量肝素在预防肺栓塞方面可能有益,但其疗效仍有待证实,适应证也有待确定。一氧化氮(NO)或NO释放剂无效,且会引起头痛。利尿剂会降低出生体重,却无法改善肺栓塞的发病率。