Fodor Andrea, Gyorffy András, Váradi Magdolna, Fülesdi Béla, Major Tamás
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Aneszteziológiai és Intenzív Terápiás Tanszék Debrecen Nagyerdei krt.
Orv Hetil. 2012 Jan 29;153(4):144-51. doi: 10.1556/OH.2012.29267.
This review summarizes the possible options for the prevention of preeclampsia based on important factors of patomechanism. The effects of antioxidants have been described in numerous clinical researches based on the oxidative hypothesis. Another important factor is the change of nitric oxide activity. Nitric oxide donors are able to compensate the symptoms of preeclampsia. The inverse relationship between the calcium intake and gestational hypertension has been known for a long time. The calcium supplementation seems to be a good opportunity to prevent preeclampsia. With low molecular weight heparins we can intervene in the patomechanisms of preeclampsia by antithrombocyte effects, vasoactive properties and impact on throphoblast cell morphology and differentiation. Thrombocyte aggregation inhibitors were examined in number of studies because they reduced thromboxane mediated vasoconstriction and inhibited placental thrombosis. Several studies verify whether prophylaxis with low molecular weight heparins and low dose aspirin could improve pregnancy outcome in preeclampsia.
本综述基于发病机制的重要因素总结了预防先兆子痫的可能方法。基于氧化假说，抗氧化剂的作用已在众多临床研究中得到描述。另一个重要因素是一氧化氮活性的变化。一氧化氮供体能够补偿先兆子痫的症状。钙摄入量与妊娠高血压之间的负相关关系早已为人所知。补充钙似乎是预防先兆子痫的一个好机会。使用低分子量肝素，我们可以通过抗血小板作用、血管活性特性以及对滋养层细胞形态和分化的影响来干预先兆子痫的发病机制。血小板聚集抑制剂在多项研究中得到检验，因为它们可减少血栓素介导的血管收缩并抑制胎盘血栓形成。多项研究验证了低分子量肝素和低剂量阿司匹林预防是否能改善先兆子痫的妊娠结局。
