Novel Tech Ethics, Dalhousie University, 1234 LeMarchant Street, Halifax NS B3H 3P7, Canada.
J Med Ethics. 2010 Apr;36(4):198-202. doi: 10.1136/jme.2009.034421.
During the past few years considerable debate has arisen within academic journals with respect to the use of smart drugs or cognitive enhancement pharmaceuticals. The following paper seeks to examine the foundations of this cognitive enhancement debate using the example of methylphenidate use among college students. The argument taken is that much of the enhancement debate rests upon inflated assumptions about the ability of such drugs to enhance and over-estimations of either the size of the current market for such drugs or the rise in popularity as drugs for enhancing cognitive abilities. This article provides an overview of the empirical evidence that methylphenidate has the ability to significantly improve cognitive abilities in healthy individuals, and examines whether the presumed uptake of the drug is either as socially significant as implied or growing to the extent that it requires urgent regulatory attention. In addition, it reviews the evidence of side-effects for the use of methylphenidate which may be an influential factor in whether an individual decides to use such drugs. The primary conclusions are that neither drug efficacy, nor the benefit-to-risk balance, nor indicators of current or growing demand provide sufficient evidence that methylphenidate is a suitable example of a cognitive enhancer with mass appeal. In light of these empirically based conclusions, the article discusses why methylphenidate might have become seen as a smart drug or cognitive enhancer.
在过去的几年中,学术期刊上就使用益智药或认知增强药物的问题展开了激烈的辩论。本文试图以大学生使用哌醋甲酯为例,探讨这种认知增强辩论的基础。本文的论点是,这种药物的增强作用的假设和对当前药物市场规模或作为增强认知能力的药物的流行程度的高估,是增强辩论的基础。本文概述了哌醋甲酯能够显著提高健康个体认知能力的经验证据,并探讨了假定的药物使用率是否像暗示的那样具有社会意义,或者是否增长到需要紧急监管关注的程度。此外,它还审查了使用哌醋甲酯的副作用的证据,这可能是个人决定使用此类药物的一个重要因素。主要结论是,无论是药物疗效、风险效益平衡,还是当前或增长需求的指标,都没有充分的证据表明哌醋甲酯是一种具有广泛吸引力的认知增强剂。鉴于这些基于经验的结论,本文讨论了为什么哌醋甲酯可能被视为一种益智药或认知增强剂。