Ribeiro Adriana Spinola, Salles Patrícia Ribeiro, da Silva Tarcília Aparecida, Mesquita Ricardo Alves
Department of Oral Surgery, Medicine and Pathology, Dental School, Federal University of Minas Gerais, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil.
Int J Dent. 2010;2010:186018. doi: 10.1155/2010/186018. Epub 2010 Feb 23.
The aim of this paper was to assess the nonsurgical treatment of oral leukoplakia (OL). A medline search from 1983 to 2009 was conducted. The topical or systemic nonsurgical treatments or combination of both was reviewed. The primary outcomes of interest were clinical resolution, malignant transformation, follow-up, and recurrence of OL. Studies showed a rate higher than 50% of clinical resolution with photodynamic therapy, beta-carotene, lycopene, or vitamin A. Few studies reported rates of recurrence from 5 to 67% and of malignant transformation from 8 to 23%. There is a lack of randomized clinical trials that assess the effectiveness of nonsurgical treatment of OL. At this time, randomized controlled trials for nonsurgical treatment of OL demonstrate no evidence of effective treatment in preventing malignant transformation and recurrence. It reinforces that even after clinical resolution, OL should be regularly followed.
本文旨在评估口腔白斑（OL）的非手术治疗。对1983年至2009年的医学文献数据库进行了检索。回顾了局部或全身非手术治疗或两者联合治疗。主要关注的结果是临床缓解、恶变、随访及OL复发。研究表明，光动力疗法、β-胡萝卜素、番茄红素或维生素A的临床缓解率高于50%。少数研究报告复发率为5%至67%，恶变率为8%至23%。缺乏评估OL非手术治疗有效性的随机临床试验。目前，OL非手术治疗的随机对照试验表明，没有证据显示在预防恶变和复发方面有有效治疗方法。这进一步强调，即使临床缓解后，OL也应定期随访。
