Ge Shuyun, Liu Lin, Zhou Qi, Lou Binbin, Zhou Zengtong, Lou Jianing, Fan Yuan
Department of Oral Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Oral Medicine, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
PeerJ. 2020 Feb 24;8:e8644. doi: 10.7717/peerj.8644. eCollection 2020.
Oral mucosal diseases (OMDs) encompass a variety of different types of diseases. Our aim was to evaluate the prevalence and related risk factors of OMDs among residents in the Baoshan District of Shanghai, China, and provide a scientific basis for prevention and control strategies.
A sample of 653 residents aged 17 to 92 years from the Baoshan community was investigated in 2014. Each resident was surveyed by questionnaire to evaluate their oral mucosa and oral mucosa examinations were conducted. We followed up with 607 residents in 2018. All data were statistically analyzed using the SPSS 25.0 software package (Chicago, IL, USA) at the general population, gender and age levels. A X test was used to compare rates of risk factors and logistic regression analysis was used to detect the correlation between disease and risk factors.
The prevalence rate of OMDs was found to be 9.19%-9.56% (2014-2018). The most common OMDs were atrophic glossitis (1.84%), recurrent aphthous ulcer (RAU, 1.68%), burning mouth syndrome (BMS, 1.38%), oral lichen planus (OLP, 1.23%) and traumatic ulcers (1.23%). The prevalence of RAU and BMS in different age groups was significantly different. Tobacco and alcohol use and psychological factors in the OMDs group were higher than the no-OMDs group. Systemic diseases including diabetes mellitus (DM) was significantly relevant to OLP.
Age, tobacco and alcohol use, and psychological factor correlated strongly with the occurrence and development of OMDs, and they should be the focus of primary prevention. General epidemiological studies suggested that OLP was closely related to DM.
口腔黏膜疾病（OMDs）涵盖多种不同类型的疾病。我们的目的是评估中国上海宝山区居民中OMDs的患病率及相关危险因素，为防控策略提供科学依据。
2014年对宝山区社区653名年龄在17至92岁的居民进行了抽样调查。通过问卷对每位居民进行调查以评估其口腔黏膜情况，并进行口腔黏膜检查。2018年对607名居民进行了随访。所有数据在总体人群、性别和年龄层面使用SPSS 25.0软件包（美国伊利诺伊州芝加哥）进行统计分析。采用X检验比较危险因素的发生率，采用逻辑回归分析检测疾病与危险因素之间的相关性。
发现OMDs的患病率为9.19%-9.56%（2014-2018年）。最常见的OMDs为萎缩性舌炎（1.84%）、复发性阿弗他溃疡（RAU，1.68%）、灼口综合征（BMS，1.38%）、口腔扁平苔藓（OLP，1.23%）和创伤性溃疡（1.23%）。不同年龄组中RAU和BMS的患病率存在显著差异。OMDs组的烟草和酒精使用以及心理因素高于无OMDs组。包括糖尿病（DM）在内的全身性疾病与OLP显著相关。
年龄、烟草和酒精使用以及心理因素与OMDs的发生和发展密切相关，应作为一级预防的重点。一般流行病学研究表明OLP与DM密切相关。
