Shu Xuemei, Wu Qiuling, Guo Tao, Yin Hua, Liu Jingdi
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2022 Mar 4;12:851406. doi: 10.3389/fonc.2022.851406. eCollection 2022.
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence. Myeloid sarcoma, which rarely happens in acute promyelocytic leukemias, is more common in recurrent patients after the advent of all-trans retinoic acid (ATRA) and are rare in untreated acute promyelocytic leukemia. We described a case of, to our knowledge, myeloid sarcoma of the spine confirmed as acute promyelocytic leukemia. Myeloid sarcoma is diagnosed by spinal tumor biopsy, and microscopic examination of a bone marrow smear and cytogenetic analysis led to a confirmed diagnosis of acute promyelocytic leukemia.
髓系肉瘤是一种罕见的未成熟髓系细胞的髓外肿瘤。某些已知的急性髓系白血病细胞遗传学异常，特别是t(8,21)，与较高的发病率相关。髓系肉瘤很少发生在急性早幼粒细胞白血病中，在全反式维甲酸（ATRA）出现后，在复发患者中更为常见，而在未经治疗的急性早幼粒细胞白血病中则很少见。据我们所知，我们描述了一例经证实为急性早幼粒细胞白血病的脊柱髓系肉瘤病例。髓系肉瘤通过脊柱肿瘤活检诊断，骨髓涂片显微镜检查和细胞遗传学分析确诊为急性早幼粒细胞白血病。
