Kodama Yasushi, Matsuura Masahiro, Sano Tomoya, Nakahara Yutaka, Ozaki Kiyokazu, Narama Isao, Matsuura Tetsuro
Laboratory of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima, Japan.
Comp Med. 2011 Feb;61(1):53-9.
Many epidemiologic studies have suggested that diabetes may be an important risk factor for periodontal disease. To determine whether diabetes induces or enhances periodontal disease or dental caries, dental tissue from diabetic male and nondiabetic female WBN/KobSlc rats and male and female age-matched nondiabetic F344 rats was analyzed morphologically and morphometrically for these 2 types of lesions. Soft X-ray examination revealed that the incidence and severity of both molar caries and alveolar bone resorption were much higher in male WBN/KobSlc rats with chronic diabetes than in nondiabetic female rats of the same strain. Histopathologic examination showed that dental caries progressed from acute to subacute inflammation due to bacterial infections and necrosis in the pulp when the caries penetrated the dentin. In the most advanced stage of dental caries, inflammatory changes caused root abscess and subsequent apical periodontitis, with the formation of granulation tissue around the dental root. Inflammatory changes resulted in resorption of alveolar bone and correlated well with the severity of molar caries. Our results suggest that diabetic conditions enhance dental caries in WBN/KobSlc rats and that periodontal lesions may result from the apical periodontitis that is secondary to dental caries.
许多流行病学研究表明，糖尿病可能是牙周病的一个重要危险因素。为了确定糖尿病是否会诱发或加重牙周病或龋齿，对雄性和雌性WBN/KobSlc糖尿病大鼠以及年龄匹配的雄性和雌性非糖尿病F344大鼠的牙齿组织进行了形态学和形态计量学分析，以检测这两种类型的病变。软X线检查显示，患有慢性糖尿病的雄性WBN/KobSlc大鼠的磨牙龋齿和牙槽骨吸收的发生率和严重程度均远高于同一品系的非糖尿病雌性大鼠。组织病理学检查表明，当龋齿穿透牙本质时，由于细菌感染和牙髓坏死，龋齿从急性炎症发展为亚急性炎症。在龋齿最严重的阶段，炎症变化导致牙根脓肿和随后的根尖周炎，并在牙根周围形成肉芽组织。炎症变化导致牙槽骨吸收，且与磨牙龋齿的严重程度密切相关。我们的研究结果表明，糖尿病状态会加重WBN/KobSlc大鼠的龋齿，并且牙周病变可能是由龋齿继发的根尖周炎引起的。
