Machado-Alba Jorge E, González-Santos Diana M
Departamento de Farmacoepidemiología, Universidad Tecnológica de Pereira, Colombia.
Rev Salud Publica (Bogota). 2009 Oct;11(5):734-44. doi: 10.1590/s0124-00642009000500006.
Analysing how systemic antibiotic agents were dispensed to outpatients in a Colombian population between January 2005 and December 2006 and assessing their economic cost as antibiotic use and abuse have been related to serious bacterial resistance.
This was a descriptive observational study of antibiotic drug use; a database was compiled from medication usage records maintained by dispensing pharmacies in 10 Colombian cities regarding the total of users who had received some type of antibiotic. The defined daily dose (DDD) and cost per 1,000 inhabitants/day were assessed. The commonly used antibiotic associations were analysed.
DDD was 1.58 per 1,000 inhabitants per day. The antibiotics most frequently prescribed were penicillin (amoxiciline; dicloxaciline), followed by first-generation cephalosporines and sulphonamides. Injectable antibiotic use was 10.4 % in 2005 and 9.3 % in 2006; an association of anti-bacterial agents was used for 11 % of the patients. Total antibiotic dispensation cost in 2005 was US$ 1,708,350 and cost per 1,000 inhabitants per day was US$ 1.13 in 2005 and US$ 1 in 2006.
DDD per 1,000 inhabitants per day and cost per inhabitant per day was low compared to other countries.
分析2005年1月至2006年12月期间哥伦比亚人群中门诊患者系统性抗生素的配药情况，并评估其经济成本，因为抗生素的使用和滥用与严重的细菌耐药性有关。
这是一项关于抗生素使用的描述性观察研究；从哥伦比亚10个城市的配药药房保存的用药记录中汇编了一个数据库，内容涉及接受某种抗生素治疗的患者总数。评估了限定日剂量（DDD）和每1000居民每日成本。分析了常用的抗生素组合。
DDD为每1000居民每天1.58。最常开具的抗生素是青霉素（阿莫西林；双氯西林），其次是第一代头孢菌素和磺胺类药物。2005年注射用抗生素的使用率为10.4%，2006年为9.3%；11%的患者使用了抗菌药物组合。2005年抗生素配药总成本为1,708,350美元，2005年每1000居民每日成本为1.13美元，2006年为1美元。
与其他国家相比，每1000居民每日的DDD和每位居民每日成本较低。
