Koneski Julio A S, Casella Erasmo B
Department of Neurology of São Paulo Medical School, São Paulo University, Joinville Region University, São Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2010 Feb;68(1):107-14. doi: 10.1590/s0004-282x2010000100023.
The association between attention deficit and hyperactivity disorder (ADHD) and epilepsy can cause significant impact on the social life of affected individuals and their families. Clinical studies suggest that 30-40% of people with epilepsy also have ADHD. There are no studies which demonstrate that short or long-term treatment with methylphenidate increases the risk of seizures. Some studies attempt to relate drug interactions between methylphenidate and antiepileptic drugs, but adverse effects of methylphenidate have not been shown clearly. This review presents some neurobiological and physiopathogenic aspects, common to ADHD and epilepsy, from recent research studies, related to pharmacology, neuroimaging and electroencephalography. Possible risk of occurrence of seizures associated with the use of methylphenidate are also discussed.
注意力缺陷多动障碍（ADHD）与癫痫之间的关联会对受影响个体及其家庭的社会生活造成重大影响。临床研究表明，30%至40%的癫痫患者也患有ADHD。尚无研究表明使用哌甲酯进行短期或长期治疗会增加癫痫发作的风险。一些研究试图探讨哌甲酯与抗癫痫药物之间的药物相互作用，但哌甲酯的不良反应尚未明确显现。本综述介绍了近期研究中ADHD和癫痫共有的一些神经生物学和病理生理学方面，涉及药理学、神经影像学和脑电图。还讨论了使用哌甲酯可能出现的癫痫发作风险。
