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抗注意缺陷多动障碍 (ADHD) 药物对临床发作和睡眠 EEG 的影响：日本 ADHD 儿童的回顾性研究。

Effect of anti-attention-deficit hyperactivity disorder (ADHD) medication on clinical seizures and sleep EEG: A retrospective study of Japanese children with ADHD.

机构信息

Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan.

Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.

出版信息

Neuropsychopharmacol Rep. 2021 Dec;41(4):511-521. doi: 10.1002/npr2.12215. Epub 2021 Oct 20.

DOI:10.1002/npr2.12215
PMID:34668641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8698674/
Abstract

AIMS

Patients with attention-deficit hyperactivity disorder (ADHD) often exhibit basic or paroxysmal wave abnormalities on electroencephalography (EEG). Methylphenidate (MPH), an anti-ADHD stimulant, has been reported to lower the seizure threshold. However, there have been no reports comparing EEG changes before and after administration of the central nervous system (CNS) stimulant MPH, or atomoxetine (ATX) hydrochloride, a non-CNS stimulant. In this study, we investigated changes in sleep EEG before and after the administration of ADHD treatment drugs.

METHOD

With the approval of the ethics committee, the medical records of 28 children with ADHD (23 men and 5 women) who gave consent were retrospectively investigated. The appearance of sudden abnormal waves during a 10-minute sleep EEG recording was measured in 0.1-second units, and the duration of these waves was calculated as the paroxysmal index (PI).

RESULTS

Paroxysmal index did not differ significantly between patients who received MPH and those who received ATX. In addition, there were no exacerbations of clinical seizures.

CONCLUSION

It was concluded that ADHD medications do not have an adverse effect on epileptic seizures or abnormal sleep EEGs.

摘要

目的

患有注意缺陷多动障碍（ADHD）的患者通常在脑电图（EEG）上显示出基本或阵发性波异常。哌醋甲酯（MPH），一种抗 ADHD 兴奋剂，已被报道降低癫痫发作阈值。然而，目前尚无关于比较中枢神经系统（CNS）兴奋剂 MPH 或非 CNS 兴奋剂盐酸托莫西汀（ATX）给药前后 EEG 变化的报告。在这项研究中，我们调查了 ADHD 治疗药物给药前后睡眠 EEG 的变化。

方法

经伦理委员会批准，回顾性调查了 28 名同意的 ADHD 儿童（23 名男性和 5 名女性）的病历。以 0.1 秒为单位测量 10 分钟睡眠 EEG 记录中突然出现的异常波的出现，并将这些波的持续时间计算为阵发性指数（PI）。

结果

接受 MPH 和接受 ATX 的患者之间阵发性指数没有显著差异。此外，没有临床癫痫发作恶化的情况。

结论

因此，ADHD 药物对癫痫发作或异常睡眠 EEG 没有不良影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/ff705b13599c/NPR2-41-511-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/2a40c323b385/NPR2-41-511-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/9b2ea205c76d/NPR2-41-511-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/e305bccc16f9/NPR2-41-511-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/a84edb082002/NPR2-41-511-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/4a3b64783075/NPR2-41-511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/46342522e74b/NPR2-41-511-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/795bea22b30a/NPR2-41-511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/e5de9a264bf4/NPR2-41-511-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/ff705b13599c/NPR2-41-511-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/2a40c323b385/NPR2-41-511-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/9b2ea205c76d/NPR2-41-511-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/e305bccc16f9/NPR2-41-511-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/a84edb082002/NPR2-41-511-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/4a3b64783075/NPR2-41-511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/46342522e74b/NPR2-41-511-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/795bea22b30a/NPR2-41-511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/e5de9a264bf4/NPR2-41-511-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b640/8698674/ff705b13599c/NPR2-41-511-g004.jpg

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