Saihara Keishi, Hamasaki Shuichi, Ishida Sanemasa, Kataoka Tetsuro, Yoshikawa Akiko, Orihara Koji, Ogawa Masakazu, Oketani Naoya, Fukudome Tsuyoshi, Atsuchi Nobuhiko, Shinsato Takuro, Okui Hideki, Kubozono Takuro, Ichiki Hitoshi, Kuwahata So, Mizoguchi Etsuko, Fujita Shoji, Takumi Takuro, Ninomiya Yuichi, Tomita Kaai, Tei Chuwa
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Heart Vessels. 2010 Mar;25(2):113-20. doi: 10.1007/s00380-009-1173-y. Epub 2010 Mar 26.
An unhealthy lifestyle can increase the risk of cardiovascular disease. However, the mechanism by which lifestyle influences the development of cardiovascular disease remains unclear. Since coronary endothelial function is a predictor of cardiovascular prognosis, the goal of this study was to characterize the effect of enjoying hobbies on coronary endothelial function and cardiovascular outcomes. A total of 121 consecutive patients (76 men, 45 women) with almost normal coronary arteries underwent Doppler flow study of the left anterior descending coronary artery following sequential administration of papaverine, acetylcholine, and nitroglycerin. On the basis of responses to questionnaires, patients were divided into two groups; the Hobby group (n = 71) who enjoyed hobbies, and the Non-hobby group (n = 50) who had no hobbies. Cardiovascular outcomes were assessed at long-term follow-up using medical records or questionnaire surveys for major adverse cardiovascular events (MACE).The average follow-up period was 916 +/- 515 days. There were no significant differences in demographics when comparing the two groups. The percent change in coronary blood flow and coronary artery diameter induced by acetylcholine was significantly greater in the Hobby group than in the Non-hobby group (49% +/- 77% vs 25% +/- 37%, P < 0.05, 4% +/- 13% vs -3% +/- 20%, P < 0.05, respectively). The MACE rate was significantly lower in the Hobby group than in the Non-hobby group (P < 0.01). Enjoyment of hobbies was the only independent predictor of MACE (odds ratio 8.1 [95% confidence interval 1.60, 41.90], P = 0.01) among the variables tested. In the early stages of arteriosclerosis, enjoying hobbies may improve cardiovascular outcomes via its favorable effects on coronary endothelial function.
不健康的生活方式会增加心血管疾病的风险。然而，生活方式影响心血管疾病发展的机制仍不清楚。由于冠状动脉内皮功能是心血管预后的一个预测指标，本研究的目的是描述享受业余爱好对冠状动脉内皮功能和心血管结局的影响。共有121例冠状动脉几乎正常的连续患者（76例男性，45例女性）在依次给予罂粟碱、乙酰胆碱和硝酸甘油后接受了左前降支冠状动脉的多普勒血流研究。根据对问卷的回答，患者被分为两组；享受业余爱好的爱好组（n = 71）和没有业余爱好的非爱好组（n = 50）。使用病历或问卷调查主要不良心血管事件（MACE）在长期随访中评估心血管结局。平均随访期为916±515天。两组在人口统计学方面无显著差异。乙酰胆碱诱导的冠状动脉血流和冠状动脉直径的百分比变化在爱好组中显著大于非爱好组（分别为49%±77%对25%±37%，P < 0.05；4%±13%对 -3%±20%，P < 0.05）。爱好组的MACE发生率显著低于非爱好组（P < 0.01）。在测试的变量中，享受业余爱好是MACE的唯一独立预测因素（优势比8.1 [95%置信区间1.60, 41.90]，P = 0.01）。在动脉粥样硬化的早期阶段，享受业余爱好可能通过其对冠状动脉内皮功能的有利影响改善心血管结局。
