Sivasankaran Satish, Pollard-Quintner Suzanne, Sachdeva Rajesh, Pugeda Jaime, Hoq Sheik M, Zarich Stuart W
Division of Cardiovascular Medicine, Department of Medicine, Bridgeport Hospital, Bridgeport, Connecticut 06610, USA.
Clin Cardiol. 2006 Sep;29(9):393-8. doi: 10.1002/clc.4960290905.
Chronic stress is estimated to increase the risk of cardiovascular (CV) events two-fold. Although stress reduction has been linked to a reduction in CV events, little is known regarding its exact mechanism of benefit.
Yoga and meditation will improve parameters of endothelial function.
We examined the effects of yoga and meditation on hemodynamic and laboratory parameters as well as on endothelial function in a 6-week pilot study. Systolic and diastolic blood pressures, heart rate, body mass index (BMI), fasting glucose, lipids, hs C-reactive protein (CRP), and endothelial function (as assessed by brachial artery reactivity) were all studied at baseline and after 6 weeks of yoga practice.
A course in yoga and meditation was given to the subjects for 1.5 h three times weekly for 6 weeks and subjects were instructed to continue their efforts at home. This prospective cohort study included 33 subjects (mean age 55 +/- 11 years) both with (30%) and without (70%) established coronary artery disease (CAD). There were significant reductions in blood pressure, heart rate, and BMI in the total cohort with yoga. None of the laboratory parameters changed significantly with yoga. For the total cohort there was no significant improvement in endothelial-dependent vasodilatation with yoga training and meditation compared with baseline (16.7% relative improvement from 7.2-8.4%; p = 0.3). In the group with CAD, endothelial-dependent vasodilatation improved 69% with yoga training (6.38-10.78%; p = 0.09).
Yoga and meditation appear to improve endothelial function in subjects with CAD.
据估计，慢性应激会使心血管（CV）事件的风险增加两倍。尽管减轻应激与心血管事件的减少有关，但其确切的获益机制仍知之甚少。
瑜伽和冥想将改善内皮功能参数。
在一项为期6周的初步研究中，我们研究了瑜伽和冥想对血流动力学和实验室参数以及内皮功能的影响。在基线时以及瑜伽练习6周后，均对收缩压、舒张压、心率、体重指数（BMI）、空腹血糖、血脂、高敏C反应蛋白（CRP）和内皮功能（通过肱动脉反应性评估）进行了研究。
为受试者提供了为期6周、每周三次、每次1.5小时的瑜伽和冥想课程，并指导受试者在家中继续练习。这项前瞻性队列研究纳入了33名受试者（平均年龄55±11岁），其中有30%患有已确诊的冠状动脉疾病（CAD），70%未患CAD。在整个队列中，进行瑜伽练习后血压、心率和BMI均显著降低。实验室参数在进行瑜伽练习后均无显著变化。与基线相比，整个队列进行瑜伽训练和冥想后内皮依赖性血管舒张功能无显著改善（相对改善率从7.2%至8.4%提高到16.7%；p = 0.3）。在患有CAD的组中，瑜伽训练使内皮依赖性血管舒张功能改善了69%（从6.38%至10.78%；p = 0.09）。
瑜伽和冥想似乎能改善CAD患者的内皮功能。
