Schramm J
Neurochirurgische Klinik, Universität Bonn.
Nervenarzt. 1991 Feb;62(2):99-107.
In a retrospective serie the results of 72 cerebral vascular malformations, operated on consecutively were reviewed: 57 AV-malformations (in 55 patients), 1 dura AV-malformation, 9 cavernomas, 1 telangiectasia, 2 venous angiomas and 2 mixed malformations. The most frequent initial symptoms were headache, epileptic seizures and intracranial bleeding. In 5 cases the initial symptom was loss of consciousness with coma. A total resection could be proved angiographically in all cases. Mortality was 0%, neurological morbidity, i.e., new deficits or increase of existing deficits, was 8.6%. There were no recurrences of bleeding in the postoperative period. Quality of life, as assessed by the Karnofsky Index 6 months postoperatively, was satisfactory, approximately 80% of all patients being back at work. In this group of selectively operated patients it could be shown that localization of the malformation in or close to an eloquent brain area (n = 32) is rarely associated with significant persisting new deficits. Taking into consideration the natural history of AV malformations, with an 8% morbidity and 2% mortality each year, as compared to the surgical results, it is concluded that surgery may be more often indicated for AV malformations than was previously thought, even when they are near eloquent brain areas and relatively large in diameter.
回顾性分析了连续接受手术治疗的72例脑血管畸形的结果:57例动静脉畸形(55例患者)、1例硬脑膜动静脉畸形、9例海绵状血管瘤、1例毛细血管扩张症、2例静脉血管瘤和2例混合型畸形。最常见的首发症状是头痛、癫痫发作和颅内出血。5例患者的首发症状是意识丧失伴昏迷。所有病例均经血管造影证实为全切。死亡率为0%,神经功能障碍发生率,即新出现的神经功能缺损或原有缺损加重,为8.6%。术后无出血复发。术后6个月通过卡诺夫斯基指数评估的生活质量令人满意,约80%的患者恢复工作。在这组选择性手术的患者中可以看出,畸形位于或靠近功能区(n = 32)很少会导致严重的持续性新神经功能缺损。考虑到动静脉畸形的自然病史,每年发病率为8%,死亡率为2%,与手术结果相比,得出的结论是,即使动静脉畸形靠近功能区且直径相对较大,手术指征可能比以前认为的更常见。