胰蛋白酶处理后人脂肪细胞中茶碱诱导的脂解作用的改变
Modification of theophylline-induced lipolysis in human fat cells after trypsination.
作者信息
Giudicelli Y, Brullé D, Nordmann R
出版信息
Experientia. 1978 Feb 15;34(2):161-3. doi: 10.1007/BF01944651.
PMID:203472
Abstract
Trypsin-treatment of human fat cells results in the potentiation of the lipolytic response and the cAMP accumulation induced by theophylline (5 . 10(-4) M) but not of those induced by theophylline (5 . 10(-3) M). The amount of cAMP formed after exposure to theophylline (5 . 10(-3) M) plus norepinephrine (5 . 10(-6) M) remains, however, 2.6 fold higher in trypsin-treated human fat cells than in the control ones.
摘要
用胰蛋白酶处理人脂肪细胞会增强由茶碱（5×10⁻⁴ M）诱导的脂解反应和环磷酸腺苷（cAMP）积累，但不会增强由茶碱（5×10⁻³ M）诱导的脂解反应和cAMP积累。然而，在胰蛋白酶处理过的人脂肪细胞中，暴露于茶碱（5×10⁻³ M）加去甲肾上腺素（5×10⁻⁶ M）后形成的cAMP量，仍比对照细胞中的高2.6倍。
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