Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Int J Epidemiol. 2010 Apr;39 Suppl 1(Suppl 1):i70-4. doi: 10.1093/ije/dyq024.
Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years.
We reviewed all literature reporting the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. We used a standardized abstraction and grading format and performed meta-analyses to determine the effect of treatment with these antibiotics on rates of treatment failure, bacteriological failure and bacteriological relapse. The CHERG Standard Rules were applied to determine the final effect of treatment with these antibiotics on diarrhoea mortality.
Eight papers were selected for abstraction. Treatment with ciprofloxacin, ceftriaxone or pivmecillinam resulted in a cure rate of >99% while assessing clinical failure, bacteriological failure and bacteriological relapse.
The antibiotics recommended by the WHO--ciprofloxacin, ceftriaxone and pivmecillinam--are effective in reducing the clinical and bacteriological signs and symptoms of dysentery and thus can be expected to decrease diarrhoea mortality attributable to dysentery.
环丙沙星、头孢曲松和匹美西林是世界卫生组织（世卫组织）目前推荐用于治疗儿童痢疾的抗生素；然而，近年来尚未对这些抗生素的临床疗效进行任何审查。
我们回顾了所有报告在发展中国家使用环丙沙星、头孢曲松和匹美西林治疗痢疾的疗效的文献。我们使用标准化的摘要和分级格式，并进行荟萃分析，以确定这些抗生素治疗对治疗失败、细菌学失败和细菌学复发率的影响。应用 CHERG 标准规则来确定这些抗生素治疗对腹泻死亡率的最终影响。
选择了 8 篇论文进行摘要。评估临床失败、细菌学失败和细菌学复发时，使用环丙沙星、头孢曲松或匹美西林治疗的治愈率超过 99%。
世卫组织推荐的抗生素——环丙沙星、头孢曲松和匹美西林——可有效减轻痢疾的临床和细菌学症状，因此有望降低痢疾导致的腹泻死亡率。
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