Kabir I, Rahaman M M, Ahmed S M, Akhter S Q, Butler T
Antimicrob Agents Chemother. 1984 May;25(5):643-5. doi: 10.1128/AAC.25.5.643.
The clinical efficacies of pivmecillinam and ampicillin were compared in a randomized double-blind trial in the treatment of acute shigellosis. Of 44 adult male patients, all culture positive for Shigella strains, 22 patients received 400 mg of pivmecillinam and 22 patients received 500 mg of ampicillin every 6 h. Both drugs were administered orally for 5 days. Four patients receiving ampicillin were infected with Shigella strains that were resistant to ampicillin but susceptible to pivmecillinam, and two patients receiving pivmecillinam were infected with Shigella strains resistant to both ampicillin and pivmecillinam. The mean duration of diarrhea in all patients receiving pivmecillinam was 3.3 days compared with 4.5 days in patients receiving ampicillin (P less than 0.05). When patients infected with the resistant strains were excluded, the mean duration of diarrhea in patients receiving pivmecillinam was 3.2 days compared with 4.1 days in patients receiving ampicillin. The patients infected with strains susceptible to both antibiotics had mean durations of fecal excretion of Shigella strains of 1.2 days for those treated with pivmecillinam and 1.4 days for those treated with ampicillin. The patients infected with organisms resistant to both drugs had longer durations of diarrhea and fecal excretion of Shigella strains. The results suggest that pivmecillinam is as effective as ampicillin and can be a useful drug for the treatment of shigellosis.
在一项治疗急性志贺菌病的随机双盲试验中，比较了匹美西林和氨苄西林的临床疗效。44例成年男性患者，所有患者的志贺菌菌株培养均呈阳性，22例患者每6小时接受400mg匹美西林，22例患者每6小时接受500mg氨苄西林。两种药物均口服给药5天。4例接受氨苄西林治疗的患者感染了对氨苄西林耐药但对匹美西林敏感的志贺菌菌株，2例接受匹美西林治疗的患者感染了对氨苄西林和匹美西林均耐药的志贺菌菌株。所有接受匹美西林治疗的患者腹泻平均持续时间为3.3天，而接受氨苄西林治疗的患者为4.5天（P<0.05）。排除感染耐药菌株的患者后，接受匹美西林治疗的患者腹泻平均持续时间为3.2天，而接受氨苄西林治疗的患者为4.1天。感染对两种抗生素均敏感菌株的患者，接受匹美西林治疗的志贺菌菌株粪便排泄平均持续时间为1.2天，接受氨苄西林治疗的为1.4天。感染对两种药物均耐药菌株的患者腹泻和志贺菌菌株粪便排泄持续时间更长。结果表明，匹美西林与氨苄西林疗效相当，可作为治疗志贺菌病的有效药物。
