全细胞百日咳疫苗免疫的巴西儿童对不同株博德特氏菌的抗体反应。
Antibody response from whole-cell pertussis vaccine immunized Brazilian children against different strains of Bordetella pertussis.
机构信息
Genetics, Virology, Biochemistry and Immunochemistry Laboratories, Butantan Institute, São Paulo, Brazil.
出版信息
Am J Trop Med Hyg. 2010 Apr;82(4):678-82. doi: 10.4269/ajtmh.2010.09-0486.
Bordetella pertussis is a gram-negative bacillus that causes the highly contagious disease known as pertussis or whooping cough. Antibody response in children may vary depending on the vaccination schedule and the product used. In this study, we have analyzed the antibody response of cellular pertussis vaccinated children against B. pertussis strains and their virulence factors, such as pertussis toxin, pertactin, and filamentous hemagglutinin. After the completion of the immunization process, according to the Brazilian vaccination program, children serum samples were collected at different periods of time, and tested for the presence of specific antibodies and antigenic cross-reactivity. Results obtained show that children immunized with three doses of the Brazilian whole-cell pertussis vaccine present high levels of serum antibodies capable of recognizing the majority of the components present in vaccinal and non-vaccinal B. pertussis strains and their virulence factors for at least 2 years after the completion of the immunization procedure.
百日咳博德特氏菌是一种革兰氏阴性杆菌，可引起高度传染性疾病，即百日咳或百日咳。儿童的抗体反应可能因接种计划和使用的产品而异。在这项研究中，我们分析了细胞百日咳疫苗接种儿童对百日咳博德特氏菌菌株及其毒力因子（如百日咳毒素、 pertactin 和丝状血凝素）的抗体反应。免疫接种过程完成后，根据巴西疫苗接种计划，在不同时期采集儿童血清样本，并检测特异性抗体和抗原交叉反应的存在。结果表明，接受三剂巴西全细胞百日咳疫苗免疫的儿童体内产生高水平的血清抗体，至少在免疫接种程序完成后 2 年内，能够识别疫苗和非疫苗百日咳博德特氏菌菌株及其毒力因子中存在的大多数成分。
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