Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Bogor, West Java, Indonesia.
Department of Biology, Faculty of Medicine, Universitas Trisakti, West Jakarta, Indonesia.
PLoS One. 2024 Sep 30;19(9):e0311362. doi: 10.1371/journal.pone.0311362. eCollection 2024.
Bordetella pertussis infection is a highly contagious respiratory disease that can cause complications such as pneumonia and death. A total of 62,646 cases of pertussis worldwide were reported by WHO in 2022. This study aimed to obtain the pertussis seroprevalence and sociodemographic data in children aged 1-14 years and its association factors in the community based on Riskesdas 2013 and 2018. Bivariate and multivariate analysis was carried out on data from 12,753 children aged 1-14 years collected from Riskesdas 2013 and 2018 in Indonesia. Pertussis serology data was obtained based on the results of the ELISA examination which was categorized as seropositive if anti-pertussis toxin IgG ≥ 100 IU/mL or anti-pertussis IgG > 11 NTU. Pertussis seropositive indicated recent pertussis infection if no pertussis vaccine was received within the last twelve months. Pertussis seroprevalence was found at 9.8% and 33.4% in Riskesdas 2013 and 2018 respectively. While 10.1% of children aged 5-14 years were found pertussis seropositive by excluding the possible effect of vaccination in the last twelve months in Riskesdas 2013. The most important associated factor in seropositive pertussis at ages 1-4 years and 5-14 years was a history of pneumonia in the last month (OR = 2.709, 95%CI: 2.592-2.831 in Riskesdas 2013 and OR = 2.421, 95%CI: 2.299-2.550 in Riskesdas 2018). In the adjusted analysis for respondents' characteristics, low maternal education was the predictive factor that most influenced pertussis seropositivity, especially in the 2013 Riskesdas (APOR = 2.983, 95%CI: 2.670-3.333). In conclusion, the results of this study showed that the seroprevalence of pertussis was high, especially in children aged 5-14 years, so that pertussis vaccine booster administration could be considered. Because the most influencing factor towards pertussis seropositive was low maternal education, the groups of children with low-educated mothers should be targets for strengthening complete vaccination coverage and disease control.
百日咳博德特氏菌感染是一种高度传染性的呼吸道疾病，可导致肺炎和死亡等并发症。2022 年，世卫组织报告全球共有 62646 例百日咳病例。本研究旨在根据 2013 年和 2018 年的 Riskesdas 数据，获得 1-14 岁儿童的百日咳血清阳性率和社会人口学数据及其在社区中的关联因素。对来自 2013 年和 2018 年 Riskesdas 的 12753 名 1-14 岁儿童的数据进行了双变量和多变量分析。百日咳血清学数据是根据 ELISA 检查的结果获得的，如果抗百日咳毒素 IgG≥100IU/mL 或抗百日咳 IgG＞11 NTU，则归类为血清阳性。如果在过去 12 个月内未接种百日咳疫苗，则提示近期百日咳感染。2013 年和 2018 年的 Riskesdas 分别发现百日咳血清阳性率为 9.8%和 33.4%。而在 2013 年的 Riskesdas 中，排除过去 12 个月内疫苗接种的可能影响后，发现 5-14 岁儿童中有 10.1%的百日咳血清阳性。1-4 岁和 5-14 岁儿童血清阳性百日咳的最重要相关因素是过去一个月内肺炎史（2013 年 Riskesdas 中的 OR=2.709，95%CI：2.592-2.831；2018 年 Riskesdas 中的 OR=2.421，95%CI：2.299-2.550）。在针对受访者特征的调整分析中，母亲文化程度低是影响百日咳血清阳性率的最主要预测因素，尤其是在 2013 年的 Riskesdas 中（APOR=2.983，95%CI：2.670-3.333）。总之，本研究结果表明，百日咳血清阳性率较高，尤其是 5-14 岁儿童，因此可以考虑加强百日咳疫苗加强免疫。由于对百日咳血清阳性影响最大的因素是母亲文化程度低，因此应将母亲文化程度低的儿童群体作为加强全面疫苗接种覆盖率和疾病控制的目标。
