Hashemi-Fesharki R
Protozoology and Entomology Department, Razi State Vaccine and Serum Institute, Tehran, Iran.
Res Vet Sci. 1991 Mar;50(2):204-7. doi: 10.1016/0034-5288(91)90107-y.
Parvaquone (BW993C), 2-cyclohexyl-3-hydroxy-1,4-naphthoquinone, and buparvaquone (BW720C) 2-(trans-4-t-butylcyclohexyl-methyl)-3-hydroxy-1,4-naphthoquinone, were evaluated to determine their therapeutic efficacy in the treatment of theileriosis caused by Theileria annulata infection in cattle in Iran. One hundred and fifty-nine pure and crossbred Bos taurus cattle, experimentally or naturally infected with T annulata, were treated. Parvaquone was injected into 86 animals with up to three doses of 20 mg kg-1 or 10 mg kg-1 at intervals of 48 hours between doses. Buparvaquone was injected into 73 animals. Up to three doses of 2.5 mg kg-1 were injected with an interval of 48 hours between doses. The recovery rate of animals treated with parvaquone was 60.7 per cent and with buparvaquone it was 88.7 per cent. No significant side effects of relapse of disease were observed following the use of either compound. It is concluded that buparvaquone at a dose of 2.5 mg kg-1 has a satisfactory therapeutic index and is a more effective treatment of T annulata infection than parvaquone. The prophylactic use of schizont tissue culture vaccine and chemotherapy with buparvaquone could be the most promising means of controlling theileriosis in Iran.
评价了萘醌（BW993C，2 - 环己基 - 3 - 羟基 - 1,4 - 萘醌）和丁萘醌（BW720C，2 - （反式 - 4 - 叔丁基环己基甲基） - 3 - 羟基 - 1,4 - 萘醌）对伊朗牛环形泰勒虫感染引起的泰勒虫病的治疗效果。对159头实验性或自然感染环形泰勒虫的纯合和杂交黄牛进行了治疗。给86头动物注射萘醌，剂量高达20mg/kg，分三次注射，每次剂量间隔48小时；或每次10mg/kg。给73头动物注射丁萘醌，每次剂量高达2.5mg/kg，分三次注射，每次剂量间隔48小时。用萘醌治疗的动物恢复率为60.7%，用丁萘醌治疗的动物恢复率为88.7%。使用这两种化合物后均未观察到明显的副作用或疾病复发。得出结论，2.5mg/kg剂量的丁萘醌具有令人满意的治疗指数，比萘醌更有效地治疗环形泰勒虫感染。在伊朗，裂殖体组织培养疫苗的预防性使用和丁萘醌化疗可能是控制泰勒虫病最有前景的手段。
