白花丹醌和百里香酚的体外抗……功效
In vitro efficacy of plumbagin and thymol against .
作者信息
Titus E Eben, Palavesam Azhahianambi, Rajaram Srinivasan Morkonda, Perumal Pandikumar, Darwin Santhaanam Sylvester, Sanmugapriya Nagul Kumar, Janarthanam Ganesh, Muthusamy Raman
机构信息
Translational Research Platform for Veterinary Biologicals, Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Madhavaram, Chennai, 600 051 India.
Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, 600 007 India.
出版信息
J Parasit Dis. 2023 Mar;47(1):152-160. doi: 10.1007/s12639-022-01550-x. Epub 2022 Nov 27.
UNLABELLED
Phytochemical compounds, plumbagin and thymol were evaluated for their efficacy against using MTT cell viability assay. Plumbagin and thymol were found to be effective in preventing the proliferation of infected bovine lymphocytes. The IC values of plumbagin and thymol were 0.019 µM and 0.009 µM, respectively. Plumbagin and thymol were found to be non-cytotoxic to the bovine peripheral blood mononuclear cells. However, both the compounds were found to have inhibitory effect on vero cell proliferation. Plumbagin had primarily anti-theilerial activity but thymol had primarily anti-mitotic activity. The in vitro efficacy and cell toxicity studies indicate the potential application of plumbagin, purified from as a lead therapeutic molecule against infection in cattle.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12639-022-01550-x.
未标记
采用MTT细胞活力测定法评估了植物化学化合物白花丹醌和百里香酚对……的功效。发现白花丹醌和百里香酚可有效阻止感染牛淋巴细胞的增殖。白花丹醌和百里香酚的半数抑制浓度（IC）值分别为0.019微摩尔和0.009微摩尔。发现白花丹醌和百里香酚对牛外周血单个核细胞无细胞毒性。然而，发现这两种化合物对 vero 细胞增殖均有抑制作用。白花丹醌主要具有抗泰勒虫活性，而百里香酚主要具有抗有丝分裂活性。体外功效和细胞毒性研究表明，从……中纯化得到的白花丹醌作为治疗牛泰勒虫感染的先导治疗分子具有潜在应用价值。
补充信息
在线版本包含可在10.1007/s12639-022-01550-x获取的补充材料。
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