Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
J Headache Pain. 2010 Aug;11(4):335-8. doi: 10.1007/s10194-010-0207-2. Epub 2010 Mar 28.
Familial trigeminal neuralgia has been reported in 1-2% of cases consistent with an autosomal dominant inheritance. We present a Swiss family with several members suffering from occipital and nervus intermedius neuralgia alone or in combination. We suggest that peripheral sensory anastomoses or central convergence of afferent pathways could explain neuralgia affecting two cranial nerves. The pedigree has two main characteristics: (1) affected individuals in two generations and (2) in the first generation the father is affected, in the second generation all women are affected, and none of the men. This is suggestive of an X-linked dominant or an autosomal dominant mode of inheritance.
家族性三叉神经痛在 1-2%的病例中与常染色体显性遗传一致。我们报告了一个瑞士家族，有几个成员患有单纯或合并的枕神经和中间神经痛。我们认为，周围感觉吻合或传入通路的中枢会聚可以解释影响两条颅神经的神经痛。该家系有两个主要特征：（1）两代中有受影响的个体；（2）第一代中父亲受影响，第二代中所有女性受影响，而男性无一例受影响。这提示 X 连锁显性或常染色体显性遗传模式。
