通过酰胺的直接钯催化α-芳基化反应，高化学选择性和对映选择性合成 3-烯丙基-3-芳基氧化吲哚。
Highly chemo- and enantioselective synthesis of 3-allyl-3-aryl oxindoles via the direct palladium-catalyzed alpha-arylation of amides.
机构信息
Organic Chemistry Institute, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
出版信息
Org Lett. 2010 May 7;12(9):1912-5. doi: 10.1021/ol1003093.
PMID:20349945
Abstract
A new NHC x Pd-catalyzed asymmetric alpha-arylation of amides is reported that gives direct access to synthetically valuable, allylated oxindoles with quaternary carbon centers. The reaction is made possible by the introduction of a new chiral NHC ligand. The palladium complexes derived therefrom combine excellent reactivity with high chemo- and enantioselectivity for the title transformation.
摘要
一种新的 NHC-Pd 催化的酰胺不对称 α-芳基化反应被报道，该反应可以直接合成具有季碳中心的合成上有价值的烯丙基氧化吲哚。该反应是通过引入一种新的手性 NHC 配体实现的。由此衍生的钯配合物具有优异的反应活性和对标题转化的高化学选择性和对映选择性。
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