Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Org Lett. 2011 Dec 16;13(24):6596-9. doi: 10.1021/ol203052y. Epub 2011 Nov 21.
The asymmetric hydrovinylation (1 mol % Ni-cat., 1 atm, ethylene, >98% ee) products from 1-methylenetetralines are readily converted into 3,3-disubstituted oxindoles and subsequently to pyrrolidinoindolines. These hydrovinylation products are also useful for the syntheses of enantiopure benzomorphans.
不对称氢甲酰化(1mol%Ni-催化剂,1atm,乙烯,>98%ee)产物 1-亚甲基四氢萘可容易地转化为 3,3-二取代的氧吲哚,随后转化为吡咯烷并吲哚啉。这些氢甲酰化产物也可用于合成对映纯苯并吗啡烷。