C₂-对称苯并咪唑盐的合成及其在钯催化酰胺分子内对映选择性α-芳基化反应中的应用
Synthesis of C₂-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides.
作者信息
He Weiping, Zhao Wei, Zhou Bihui, Liu Haifeng, Li Xiangrong, Li Linlin, Li Jie, Shi Jianyou
机构信息
School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
出版信息
Molecules. 2016 Jun 8;21(6):742. doi: 10.3390/molecules21060742.
A series of C₂-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities.
一系列C₂对称的手性苯并咪唑盐，即N-杂环卡宾配体的前体，由1,2-二溴苯设计合成。原位制备的相应卡宾在酰胺的不对称钯催化分子内α-芳基化反应中进行了测试，得到了高产率和中等对映选择性的手性二芳基甲醇。
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